IA (June 15, 2017) – Reflecting its
mission to provide innovative solutions to the genomics community, Integrated
DNA Technologies (IDT) introduces its unique rhAmp™ SNP Genotyping System,
enabling researchers to make accurate and confident SNP calls both quickly and
cost-effectively. rhAmp technology uses a unique RNase H2/DNA polymerase two-enzyme system coupled with RNA-DNA hybrid primers to
eliminate non-specific amplification and primer dimer formation, which are
challenges for other genotyping chemistries. The rhAmp SNP chemistry matches
the current market leader for accuracy (greater than 99.5% call accuracy in over
90% of assays), and has the added benefit of providing simple, fast, and
affordable genotyping results, with assays shipped in less than 7 business days.
time and simplifying the workflow, rhAmp SNP features an easy-to-use, single-tube assay setup that is
easily automated and designed to work on all leading
commercially available qPCR platforms. IDT
goes one step further with its rhAmp SNP portfolio to provide researchers with
a comprehensive solution comprising all the components needed to generate high
quality genotyping data. This includes the largest commercially available
predesigned assay collection (including ADME-specific assays) covering more
than 10 million human SNPs, an optimized master mix, a universal reporter
system, and the option to include gBlocks® Gene Fragments as
synthetic control templates. Custom assay design is also available for proprietary
and non-human SNP designs. Moreover, IDT’s rhAmp Genotyping Design Tool is able
to deliver designs in difficult sequence regions, as this innovative technology
can accommodate very short amplicons (as small as 40 bp).
The rhAmp SNP portfolio includes a
range of product sizes and formats to cost effectively address projects of all
sizes. These include an extra-small size assay (100 reactions) to enable affordable
SNP biomarker validation studies, up to the large size assay (6000 reactions)
to facilitate cost effective screening studies for large sample cohorts.
CEO Dr Joseph A. Walder commented, “We are very excited to release our first
comprehensive product line based on RNase H2 chemistry. The added specificity provided by
RNase H2 mediated primer cleavage, combined with the suppression of primer
dimer formation, make RNase H2-dependent PCR technology very useful in a
broad array of PCR applications."
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Integrated DNA Technologies
(IDT) is the world leader in delivering custom nucleic acid products for the
life sciences market in the areas of academic research, medical diagnostics,
biotechnology, agriculture, and pharmaceutical development. The company’s
primary business is the production of custom oligonucleotides for molecular
biology applications. IDT has developed proprietary technologies for genomics
applications, such as next generation sequencing, CRISPR genome editing, qPCR,
and RNA interference. Through its GMP services, IDT manufactures products used
in diagnostic tests for cancer and most inherited and infectious diseases. For
more information, visit www.idtdna.com.